Corticobasal Syndrome (CBS) / Corticobasal Degeneration (CBD)
Corticobasal Syndrome (CBS) and Corticobasal Degeneration (CBD) are rare progressive neurological conditions that affect movement, thinking, and behavior.
What is the difference between CBS and CBD?
- Corticobasal Syndrome (CBS) refers to the set of symptoms a person experiences.
- Corticobasal Degeneration (CBD) is the specific disease process found in the brain (a type of tauopathy) that is one possible cause of those symptoms.
In everyday language, people often use the terms interchangeably. Tracy was originally diagnosed using older language (“Basal Ganglionic Cortico Degeneration”), which is an earlier name for what is now called Corticobasal Degeneration.
How is it different from typical Parkinson’s disease?
CBS/CBD is considered an “atypical Parkinsonism.” Unlike classic Parkinson’s disease:
- Symptoms are usually strongly asymmetric (much worse on one side of the body)
- Standard Parkinson’s medications such as levodopa often provide little or no lasting benefit
- People frequently develop problems with purposeful movement (apraxia), dystonia, myoclonus (muscle jerks), and sometimes the “alien limb” phenomenon
- Speech, swallowing, and balance difficulties are common
- Cognitive and behavioral changes can also occur
Current treatment
There is currently no treatment that slows or stops the progression of CBD. Care focuses on managing symptoms and supporting quality of life. This may include:
- Physical, occupational, and speech therapy
- Botulinum toxin (Botox) injections for dystonia or excessive muscle contraction
- Medications to help with specific symptoms
- Caregiver support and adaptive equipment
Research
Research into tau-related diseases (including CBD and progressive supranuclear palsy) is active. Scientists are studying therapies that target the abnormal tau protein, but none are yet approved specifically for CBD/CBS.
This foundation exists to support people living with these conditions, share accurate information, and encourage continued research.
For additional information about Corticobasal Syndrome and Corticobasal Degeneration, visit:
- National Institute of Neurological Disorders and Stroke (NINDS)
- CurePSP
- National Organization for Rare Disorders (NORD)
Information on this website is provided for educational purposes and is not a substitute for professional medical advice, diagnosis, or treatment.